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KMID : 0363219930310010065
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Korean Journal of Dermatology
1993 Volume.31 No. 1 p.65 ~ p.71
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Epidermal Glucose Content and Hexokinase Activities of Diabetic Patients with Xerosis
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이승헌
이형순/이은소/임재철/최응호/김현만/김동건
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Abstract
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It is well estabilshed that the xerosis is closely related to diabetic pruritus. Although the causes of xerosis are thought to be the abnormalities of sweating and autonomic nervous system, the exact mechanism of the xerosis in diabetic skin is
still
unknown.
This study ws designed to investigate the possible derangement of glucose metabolism in the skin of diabetes mellitus patients with xerosis.
The epidemal glucose content and hexokonase activities were measured in the skin samples obtained from normal individuals and diabtes mellitus patients with xerosis. The epidermal glucose content was measured by the enzymatic cycling method. The
enzymatic activities of hexokinase were assayed by fluorometric method.
The epidermal glucose content of diabetic patients increased approximately twice [27.46±9.52(mmole/kg dry weight)] that of normal individuals [13.90±4.79(mmole/kg dry weight)](P<0.0001). the epidermal hexokinase activities of diabetes patients
were
significantly decreased[0.56±0.15(mole/hr/kg/dry weight )] compared to that of normal individuals [0.96±0.24(mole/hr/kg dry weight)] (P<0.0001). There were no significant differences in the epidermal glucose content and enzyme activities of
hexokinase
between the diabetic patients with xerosis and diabetic patients without xerosis.
These data indicated that decreased activities of hexokinase could reduce the glucose phophorylation and uptake into keratinocytes, and which could lead to accumulate glucose in the interstitial space of diabetic epidermis. And the decreased
hexokinase
activities may exert on lipid metabolism and glycolysis of diabetic epidermis, because hexokinase is a key enzyme of hexose monophosphate pathway and glycolysis.
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KEYWORD
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